Solid-State Properties of Pharmaceutical Materials

Byrn has founded and directed several programs at Purdue University including CAMP, the Center for AIDS Research, the Molecules to Market program, and Purdue’s graduate programs in regulatory and quality compliance. He has published over a dozen of papers in peer-reviewed journals and is a co-inventor of four US patents.  . He was the recipient of the APhA Ebert Prize in 1984 and 2001, the AAPS Dale E. Jordan Professor

Presents a detailed discussion of important solid-state properties, methods, and applications of solid-state analysisIllustrates the various phases or forms that solids can assume and discussesvarious issues related to the relative stability of solid forms and tendencies to undergo transformationCovers key methods of solid state analysis including X-ray powder diffraction, thermal analysis, microscopy, spectroscopy, and solid state NMRReviews critical physical attributes of pharmaceutical materials, mainly related to drug substances, including particle size/surface area, hygroscopicity, mechanical properties, solubility, and physical and chemical stabilityShowcases the application of solid state material science in rational selection of drug solid forms, analysis of various solid forms within drug substance and the drug product, and pharmaceutical product developmentIntroduces appropriate manufacturing and control procedures using Quality by Design, and other strategies that lead to safe and effective products with a minimum of resources and time

The text is split into four parts which include physical forms of pharmaceutical solids, methods of analysis, critical properties of pharmaceutical solids, and important applications of physical characterization.The methods covered within these parts will allow the reader to design, formulate and manufacture desirable solid forms for drugs.Solid State Properties of Pharmaceutical Materials features:An introduction to solid state pharmaceuticals such as amorphous form, mesophase, polymorph, hydrate/solvate, salt, co-crystal, nano-particles, solid dispersionIntensive discussions about characterization techniques such X-ray powder diffraction, thermal analysis, microscopy, spectroscopy, and solid state NMRRigorous reviews of quality attributes of pharmaceutical solids such as particle size/surface area, water sorption, dissolution, solubility, mechanical properties, physical stability, and chemical stabilityA thorough presentation about app